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2008.01.25 16:49 Emulation
Emulation News and Discussion.
2009.08.04 22:03 Marvel Comics
This is a subreddit dedicated to Marvel Comics, its publications and hundreds of characters. It is not affiliated with Marvel Entertainment, LLC and is an unofficial community operated by dedicated fans.
2023.06.09 20:01 LATE_SH0W I can't find the webui-user.bat file. Wat do I do
2023.06.09 19:28 elborracho420 Dark Coin Roadmap Update
We are excited to share the updated roadmap for the Dark Coin project, outlining key milestones and proposals for the upcoming quarter. We've made some updates and improvements over at dark-coin.io
to help keep track of our progress so far, as well as our path forward. Our focus remains on community empowerment, decentralization, and developing the Dark Coin project. Here are the highlights:
1.) Multi-Sig Election Scheduled (July-August 2023): In line with our commitment to decentralization, we will facilitate an election process to select multiple community representatives. These elected users will exercise control over the creator wallet and project funds using multi-signature functionality. This democratic approach enhances representation and fosters a stronger community.
2.) DAO Proposal: Arena Bossfights (Lottery): Our team is preparing a proposal to further enhance the Dark Coin Arena. This exciting new feature will enable users to engage in thrilling boss fights and captivating questlines using their character NFTs. Stay tuned for more details on this immersive gaming experience.
3.) DAO Proposal: Game Project(s): We are exploring additional game projects, including ASA Defender, a playful twist on the classic Asteroids game. These proposals will be presented through the Dark Coin Council system, where community members can discuss and approve the projects' specific details and the integration of Dark Coin within these games.
4.) DAO Proposal: Dark Coin xGov Proposal: We invite the community to vote on whether the Dark Coin team should pursue an xGov proposal for project funding. As a grassroots project, our funding primarily relies mostly on team member and community donations and project NFT sales. It is crucial to carefully consider the implications and potential benefits of this proposal for the future of Dark Coin.
5.) Integration of Council dApp with Discord Bot: To streamline communication and enhance transparency, we are developing a Discord bot that will automatically update the DAO channel in our Discord server with proposal information and vote results, ensuring that community members are promptly informed and engaged in the decision-making process.
6.) Technical Documentation page: Further development of the dark-coin.io
page to serve as the technical documentation page for the Dark Coin project. Significant progress has already been made with changes deployed to the page, and we are working to further improve the design and information. This page will host the project roadmap, darkpaper, and links all relevant project socials from across all channels. The big picture plan here is for the DAO to take control of the roadmap, allowing the community to decide our best path forward using the Council dApp.
7.) Development of Rewards Claim dApp Features: We have already implemented a "rewards" section on our dApp, allowing users to claim reimbursements owed during the transition to the V2 token. Building on this foundation, we are expanding the features to accommodate other project airdrops. Users will be able to conveniently claim drops directly from our website at dark-coin.com
We are thrilled about the progress and upcoming developments in the Dark Coin project. Your support and active participation are vital in shaping the future of our community-driven ecosystem. Stay engaged, provide feedback, and join us as we continue to push forward.
submitted by elborracho420
to DarkCoinASA [link] [comments]
2023.06.09 18:53 hopb4running Not a bad haul for Quick Play in 24 ML
2023.06.09 18:38 PlayersEdgePicks AI Lottery App Predicts 2 Jackpot Matches in June7 Powerball Drawing
2023.06.09 17:34 Jayrodw Got wide incision today on toe nervous for biopsy results again? Should I be?
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These were my first biopsy results from my shave biopsy. I was told it isn’t cancer yet but some of these terms in the initial biopsy result confuse me. Is there a chance they find out that it is cancer in this second biopsy? Or will they just find the same “precancerous” cells as before if anything. submitted by Jayrodw to Melanoma [link] [comments]
2023.06.09 16:57 Provat_14 এডমিশনের সময় যখন HSC এর GPA কোনো কাজেই আসে না
2023.06.09 16:14 Cpt-Dooguls Psychiatrist mishandled my information
Last year, my and I got new insurance through her job. As a result I informed my psychiatrist of the change and sent him my info. Fast forward to January he tells me it didn't go through and to just send him my new insurance card again to clear it all up. He informed me everything will be ok. Turns out he tried using my old one. A few days ago I had ago, I had my check up with him and he again stated it didn't go through. This time because the deductible was too high. I informed him it was his fault and he proceed to brush me off by saying he will send the bill to me and that insurance will sort it out/ What are my option? I am in MD, I have texts and emails to prove he mishandled my info and now wants me to pay a large sum of money. He won't even send the bill. It's been days.
submitted by Cpt-Dooguls
to legaladvice [link] [comments]
2023.06.09 16:13 noblazinjusthazin 1 day post-op from Septoplasty, Turbinate Reduction, Maxillary Antrostomy
I had my surgery yesterday and after bleeding profusely, I already feel better. The inflammation for me was not terrible, the pain was mostly a burning sensation at first but has since stopped.
I’m so pleased with initial results, I honestly don’t know why I waited so long to do this.
For anyone that can’t breathe for shit, gets brutal and sweeping allergy attacks, and struggles with aggressive sinus infection: please look into it!!!
Find a well respected ENT, and them about the procedure and quell your concerns. I see sporadic comments here about “empty nose syndrome” and from my ENT said he’s never seen it, caused it, or understand the hysteria behind it.
Don’t be turned off from some WebMD shit, this was totally worth it from my perspective!
Can’t wait to be able to breathe through my nose unobstructed!
submitted by noblazinjusthazin
to Sinusitis [link] [comments]
2023.06.09 11:12 hoyaman_99 Is it worth it to grow homegrow? (With my current setup)
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NorthWest DC guy here checkin in. The money I currently can devote to my setup is minimal at best, no major equipment upgrades plans for the foreseable future. Man this hobby can be expensive to produce quality bud. Here is my situation... submitted by hoyaman_99 to Rva_homegrown [link] [comments]
Have a garage space, like half of a 8 x 20 because the rest is filled with family stuff. I currently have it split into 2 spaces, 1 open and 1 4x4x6 tent.
I start all my seedlings indoors in my basement then transfer them to the garage. The garage is on a 15 amp circut breaker split from the house (underpowered yep) and the fuse pops if I put too much stress on it.
I own 1 300watt MCH light, 1 600watt MH/HPS (dimable), and 1 300watt LED Mars Hydro but can never run all 3 at once and fans at the same time.
I did the best I could with this setup last round and really pushed what was possible. Result is about (8) jars from the plants I flowered in the open space and (13) jars from the 3 plants I ran in the tent. Larf was real because I didnt overly train just topped. The smoke is decent I would say fruity terps and a medium high, really solid daily smokin bud.
Full rec coming to MD short term will be a shitty market but longterm it could be competative pricing with DC having to compete in a sene. I have my DC med card and LOVE Alt Sol flower but I cant grow anything close to it with my current setup, or afford to be buying their stuff for daily smoke.
SO FELLOW GROWMIES...should I just give it a break till I can upgrade my power situation and then potentially wall off the back half of the garage for good, no more temp like setup?
I would totally throw myself into outdoor growing but thats not in the cards either atm.
My friend with a two room attic setup and all the amps he needs grows some FIRE bud, hes got some high powered lights, more indoor temps, and more experience workin for him.
With the garage, man my plants early in veg went through HELL (low temps). IDK something about most storebought cannabis feels like it lacks real soul or character comapred to homegrown small batch bud, am I being a snob here?
Thats my rant for the moment, appreciate any insights or feedback.
2023.06.09 10:54 mahbubosmane How to Make Money With a Blog or Website (37+ Ways)
| || | submitted by mahbubosmane to u/mahbubosmane [link] [comments]
Making money with a blog or website - https://mahbubosmane.com/how-to-make-money-with-a-blog/
has become an increasingly popular and lucrative venture in today's digital age. To capitalize on this exciting opportunity, there are several effective strategies you can employ to generate a steady income stream. First and foremost, it is crucial to focus on creating high-quality, engaging content that caters to your target audience's interests and needs. By consistently producing valuable and informative articles, blog posts, or videos, you can attract a loyal readership and increase traffic to your site.
In addition to creating great content, implementing search engine optimization (SEO) techniques will further enhance your website's visibility in search engine results. By optimizing your website's structure, using relevant keywords, and acquiring backlinks from reputable sources, you can improve your organic search rankings and attract more visitors.
Once you have established a substantial audience and generated a significant amount of traffic, you can monetize your blog or website through various means. One popular method is affiliate marketing, where you promote products or services from other companies and earn a commission for each sale or referral you generate. Another option is to offer sponsored posts or advertisements, where you partner with brands or businesses that align with your niche and promote their products or services for a fee.
Furthermore, you can create and sell your own digital products or services, such as e-books, online courses, or consulting services. This allows you to leverage your expertise and knowledge to provide value to your audience while generating revenue.
Building a strong brand and actively engaging with your audience through comments, social media, and email newsletters are also vital for monetizing your blog or website. By fostering a sense of community and establishing yourself as an authority in your niche, you can attract more opportunities for collaborations, sponsorships, and partnerships.
It is important to note that monetizing a blog or website requires patience, persistence, and dedication. Generating substantial income may take time as you build your audience, establish credibility, and refine your monetization strategies. Continuously adapting to market trends, staying up-to-date with industry developments, and regularly analyzing your website's performance is crucial for long-term success.
In conclusion, with the right approach and a commitment to providing valuable content, a blog or website can be a profitable venture. By focusing on creating engaging content, implementing SEO strategies, and exploring various monetization methods, you can turn your online platform into a sustainable source of income.
Learn more: https://mahbubosmane.com/how-to-make-money-with-a-blog/
2023.06.09 09:02 NextGenBot Discussion: 2023 French Open (Friday, June 09, 2023)
submitted by NextGenBot
to tennis [link] [comments]
2023.06.09 03:28 YearZero All Model Leaderboards (that I know)
Here are all the ones I know so far, did I miss any? Maybe they should be shoved into the sidebawiki somewhere? I have a tab open for each of them, because Johnny-5 must have input. First, here's _underlines_ collection of leaderboards already compiled: https://github.com/underlines/awesome-marketing-datascience/blob/mastellm-tools.md#benchmarking Here are the ones I have: https://huggingface.co/spaces/HuggingFaceH4/open_llm_leaderboard https://llm-leaderboard.streamlit.app/ https://chat.lmsys.org/?leaderboard https://huggingface.co/spaces/mike-ravkine/can-ai-code-results https://github.com/the-crypt-keepecan-ai-code/tree/main
(github for can-ai-code) https://docs.google.com/spreadsheets/d/1ikqqIaptv2P4_15Ytzro46YysCldKY7Ub2wcX5H1jCQ/edit#gid=0 https://tatsu-lab.github.io/alpaca_eval/ https://docs.google.com/spreadsheets/d/1NgHDxbVWJFolq8bLvLkuPWKC7i_R6I6W/edit?usp=sharing&ouid=102314596465921370523&rtpof=true&sd=true
That's all I got! It's a lot, and all of them are incomplete, and some of them aren't great at certain things, and others are possibly making mistakes in their testing (cough
hugginface) but by their powers combined they are captain leaderboards.
They have been peppered in this sub as they came online, and I've been collecting them like pokemon, so I just wanted to share for all y'all's convenience. Go ahead, open a tab for each of them. Also another tab for huggingface "ggml" search. And another for koboldcpp github releases. Then start hitting F5 on all of them all day. Then pray to the Borg you have RAM left over for running models. Don't forget the tab for "AI Explained" YT channel, that dude is great! Additional leaderboards from comments: https://crfm.stanford.edu/helm/latest/?group=core_scenarios https://github.com/my-other-github-account/llm-humaneval-benchmarks https://github.com/FranxYao/chain-of-thought-hub https://cevalbenchmark.com/static/leaderboard.html https://bellard.org/ts_serve https://docs.google.com/spreadsheets/d/1TYBNr_UPJ7wCzJThuk5ysje7K1x-_62JhBeXDbmrjA8/edit#gid=0 https://github.com/aigoopy/llm-jeopardy
submitted by YearZero
to LocalLLaMA [link] [comments]
2023.06.09 02:55 Alarming-Seesaw2788 HSIL cin 2 can this turn cancerous quickly ?
Sex: female Age: 57 years Race: Hispanic Ongoing medical conditions : T2DM (well managed) my Medications: 500 mg metformin
Long story short; my mom has been living abroad in El Salvador for a couple months now, recently my aunt had her annual well woman exam and my mom realized she hasn’t done hers in a couple years and decided to schedule a pap in El Salvador. Pap came back abnormal then gyno referred her to a colposcopy. Colposcopy results came back as HSIL cin 2 with moderate dysplasia. The gyno is recommending LEEP procedure asap but I would like my mom to get the procedure done in the U.S. insurance is not an issue, but she’s not scheduled to come back to the U.S. until 4 more months from now. MD in el salvador states this is an urgent matter (but she’s also private pay) Is it likely that this may turn cancerous during this time Frame?
submitted by Alarming-Seesaw2788
to AskDocs [link] [comments]
2023.06.09 02:53 Odd-Manufacturer-940 Preliminary labs vs two months on this dosing schedule
submitted by Odd-Manufacturer-940 to trt [link] [comments]
2023.06.09 01:59 Satomi9 Day 1 CPT Universities Comparison Guide: Monroe vs HU vs NEC vs SPU
General comparison table of 4 universities:
|Monroe college ||Harrisburg University of Science and Technology ||New England College ||Saint Peter's University |
|Established since 1933 ||Established since 2001 ||Established since 1946 ||Established since 1872 |
|Accredited by MSCHE (Middle States Commission on Higher Education) ||Accredited by MSCHE (Middle States Commission on Higher Education) ||Accredited by NECHE (New England Commission of Higher Education) ||Accredited by MSCHE (Middle States Commission on Higher Education) |
|New Rochelle, New York ||Harrisburg, Pennsylvania ||Henniker, New Hampshire ||Jersey City, New Jersey |
|3 enrollment windows (April, September, January) ||6 enrollment windows (Jan, Mar, May, July, Aug, Nov) ||6 enrollment windows (Jan, Mar, May, July, Aug, Oct) ||4 enrollment windows (Feb, May, Sep, Nov) |
|2-3 hours/week to complete homework ||2-3 hours/week to complete homework ||2-3 hours/week to complete homework ||3-4 hours/week to complete homework |
|Onsite : Once a month ||Onsite : Once a month ||Onsite : Once a semester ||Onsite : Twice a semester |
|$11,226-$18,288 per year ||$16,440 per year ||$16,944-18,704 per program ||$25,000-28,000 per program |
Day 1 CPT program： Monroe college:
MBA Harrisburg University of Science and Technology
MS CS (STEM)
MS Data Science (STEM)
Data Science Certificate
MS Health Care Administration
Master of Public Health
Master of Public Administration
MS Criminal Justice
MS Forensic Psychology
MS Executive Leadership in Hospitality Management
Master of Arts in Teaching
MS Analytics New England College
MS Consumer Behavior and Decision Sciences
MS Computer Information Sciences
MS Cybersecurity Operations and Control Management
MS Healthcare Informatics
MS Human-Centered Interaction Design
MS Information Systems Engineering & Management
MS Learning Technologies and Media Systems
MS Pharmaceutical Sciences
MS Project Management
Executive MBA Saint Peter's University
Project Management & IT (Executive M.S.)
Data Analytics (Executive M.S.)
Information Technology and Cybersecurity (Executive M.S.)
MS Business Analytics
MS Data Science
Share some admissions experience I found on various websites： Monroe College
After conducting extensive research, I ultimately chose Monroe. Harrisburg University of Science and Technology
The main reason was stability. Monroe is a legitimate school located in New York, which means there are fewer students specifically targeting Day 1 CPT. I chose this school to avoid potential H-1B lottery issues in the future, where the immigration authorities might question my intention of pursuing further education as a means of immigration sponsorship. Considering I already had a master's degree from the United States, I was concerned about being suspected of having impure motives.
Additionally, the location of the school in New York was convenient for me in terms of transportation, and the cost-effectiveness of tuition compared to Harrisburg University next door was higher.
Furthermore, when I applied, I sought assistance from GoElite, and their advisors patiently guided me in choosing a school. They even waived the application fee for me and secured a $600 scholarship.
Moreover, Monroe offers cheaper tuition for international students who already hold a master's degree in the United States. For students with a bachelor's degree but no master's degree, the standard tuition for the master's program is $6,096 per semester, with three semesters per year, resulting in an annual tuition of $18,288. For students who already have a master's degree and plan to pursue a second master's degree, the tuition is around $3,742-4,054 per semester, with three semesters per year, resulting in an annual tuition of approximately $11,226-12,162.
Finally, a friend recommended Monroe based on his own experience, having faced all the challenges of studying in the United States. Whenever he encountered difficulties, the school staff were always willing to help, especially when he received an RFE (Request for Evidence) asking for additional documents. The school provided him with a comprehensive package, including a student ID, payment receipts, attendance records, and transcripts. Most importantly, the school office provided him with a letter stating the following response regarding CPT: 'As part of the MBA degree program, Curriculum Practical Training is an integral part of the established curriculum offered by the school and is in compliance with Student and Exchange Visitor Program requirements.' In the end, my friend smoothly satisfied the RFE requirements.
Harrisburg University of Science and Technology may be more suitable for students in STEM fields, as the school offers strong programs in those areas. As a humanities student myself, I didn't consider this school too much since there weren't suitable programs for me at the time. New England College
Harrisburg University is located in Harrisburg, Pennsylvania, with a campus in Philadelphia as well. The university focuses on undergraduate and graduate programs in STEM-related fields, boasting a strong faculty with many professors holding executive positions in companies. The school emphasizes the application of classroom learning to real-world scenarios, so most courses involve practical assignments or projects related to actual work, and students are required to participate in internships at companies. Moreover, the university offers a wide range of selectable programs to meet the personalized needs of students.
For graduate students, two courses are required per semester, one online and the other in-person. The online course involves weekly group discussions, writing assignments, quizzes, and other tasks. The in-person course takes place on the first day of the semester, one day during the semester, and the last day of the semester at the main campus in Harrisburg. On average, students need to allocate 6-8 hours per week to complete all their learning and coursework.
This university has multiple enrollment windows, with six throughout the year, which can accommodate the urgent admission needs of students.
For F-1 visa students, the general requirement is to begin the CPT (Curricular Practical Training) course internship on the first day of the first semester (Day 1 CPT full-time work). Students who have submitted an I-539 change of status application, as well as those whose B-1/B-2 or F-2 to F-1 status conversion has been approved, or students who have entered the US to begin studying under F-1 status, can only continue with CPT in the second semester after completing the first semester and achieving a GPA of 3.0 or above.
The tuition at Harrisburg is relatively high, but based on comprehensive student feedback, it is considered to be 'worth it'. After receiving an acceptance letter, a non-refundable deposit of $1,000 (USD) is required, which can be applied towards the first semester's tuition.
Established in 1946, New England College is located in Henniker, New Hampshire. It is closer to the New England region of the United States, so students from places like Boston can consider this school. However, their admission requirements may exclude some international students. For example, students who have only obtained a bachelor's degree cannot apply for the Executive program that includes CPT, and they must have already obtained a master's degree in the United States to meet this threshold. Saint Peter's University
Although the school currently does not offer any scholarships for this program, the tuition is comparatively lower than the other three schools. The entire program, completed in five to six semesters, costs around $15,000 to $16,000, which is cheaper than the popular Trine University. Interested students can also contact GoElite, as they can help waive the application fee. Though it may not be much, every little bit counts.
The college also offers six different enrollment windows throughout the year, as shown in the table above. There may be slight variations each year, but it generally falls within those months. All the graduate CPT programs offered by the school are referred to as Executive programs, and CPT is a mandatory option rather than an elective. So, prospective students applying to this liberal arts college should take note that they must have their own job. If unfortunate circumstances arise, such as being laid off during the semester, it is said that the school allows a 60-day unemployment period for students to seek new employment.
Saint Peter's University also boasts excellent comprehensive qualities. Firstly, the school is located in Jersey City, New Jersey, and the transportation is truly convenient. The straight-line distance from campus to Wall Street is less than 3.5 miles. It takes only 12 minutes by subway to reach Manhattan, and the subway can also directly take you to other core areas of New York or Newark Airport and JFK Airport.
The range of majors eligible for Day-1 CPT at the university is relatively limited, with only two options: MS Data Science and MS Business Analytics.
Saint Peter's University has four enrollment windows each year, namely the spring, summer, fall, and winter semesters. The application deadline is four weeks before the start of the semester, but sometimes the student quota fills up, so the deadline may be moved up. If you have missed the deadline, you can consider contacting GoElite, as they can arrange early interviews through internal cooperative channels with professors. It is said that the quickest turnaround time for receiving an admission letter and I-20 is 3-5 days.
The attendance requirement at the university is two weekends (Saturday to Sunday) per semester for onsite classes. The remaining courses can be completed online. The school's attendance policy explicitly states that missing one weekend's classes will result in an "absent" attendance record for the entire semester, and the school will immediately terminate the student's F-1 status.
Hope this helps!
submitted by Satomi9
to Day1CPTuniversities [link] [comments]
2023.06.09 00:08 Aggravating-Candy325 Can anyone help? my doctor is out of town for the week…
2023.06.08 22:32 cbjohnson73 Roger the Apothecary, and some others, Please Help.
Hi all, my biological surname would've been Layne per tradition, so I've been looking into the Layne genealogy. I've found LOADS about Lanes and Laynes I must relate to in some way or another. One of Samuel Lane's (b. 1628 traveled to MD with his mother Alice Carter) great-grandsons is Corbin Lane, labeled a patriot by the DAR, and as far as I've been able to find there is little to no information on his descendants. He only listed 2 of his children in his will and is believed to have had at least 8. The lists of the suspected children generally do not include one of my ggfs, except for the one by the Scott Co, VA genealogy group on FB. This is the ONLY place I've seen 'my' specific Benjamin H Lane (Sr?) b. 1787 d. 1870. Supposedly the one who married Mary D. McClelland. They supposedly had John McClelland Lane, who supposedly had Benjamin H(arris?) La(y)ne b 1844 and added the 'y' after deserting the CSA to fight in the Union and moved to KY, who supposedly married a "Polly Strong". Little seems to be known of her at all. They supposedly had James Strong Layne. Now where I have found various death records connecting these generations, I'm not sure if I'm correct given many of each of their contemporaries had the same name, oft similarly named but different parents, and similarly named but different children and siblings, often in similar areas (KY, VA, likely NC, maybe even OH). What I am certain of is that some "Jim Layne and Mary Mckee" had my 2nd ggf Oscar Layne(either no middle name or Curtis, unsure) m. Jennie Belle Barnette, they had my ggf Charles Richard Layne (1928 to 1960). The rest are living or the spouse of a living person. Sources I've gone through are works from Floyd Benjamin Layne, A Russell Slagle, and I can't remember the author's name, but a book about Lane genealogy from before the colonial days that go back to Adam De La Lona, supposedly a norman knight at the Battle of Hastings 1066. There is a book that was written in 2020 about Lane genealogy, but I haven't found it digitized anywhere. I have also looked through a LOT of records attempting to be certain of my lineage.
Another problem. Samuel Lane is often confused with one of contemporaries born around the same time, or who might just be the same person. I believe either Floyd or A. Russell made a strong argument for which to refer to as Corbin's ancestor. So I'm comfortable enough with that potential confusion. Said author then established that Samuel's father must've been (CPT?) Richard Lane, a merchant Taylor b. 1596 d. 1657 when he drowned with his son Oziell. His wife Alice and their children then moved from the Bahamas to MD iirc. What I am VERY confused with is Richard's supposed father. Roger Lane, the Apothecary, of Hereford b abt. 1565 d 1603, husband of Beatrix or Beatrice (how her name was written in his will).
There's evidence through one of his nephew's coat of arms1
that he relates to the Adam de la Lona line through William Lane I b abt. 1440. However, there is another coat of arms2
which has a better documented origin and chain of inheritance and is evidence that Roger is ACTUALLY the brother of Sir Ralph Lane b. 1535 d. 1603, explored Roanoke, yes that Roanoke and that expedition. The confusion comes from the Lanes of Hereford having no documentation of Roger's birth there, but oral tradition claims the Lane family had been there for essentially as long as possible and further descendants claim their forefathers saw the ladies and lords of old England. These oral traditions do not seem to agree. The archives that have been digitized by Hereford have not been very fruitful. If he is Sir Ralph Lane's brother, then he should've been born in Northampton in or around Orlingbury Manor, which does have a record of Sir Ralph Lane's brother Roger, but that begs the question who is the Apothecary? The previously mentioned authors have theorized seemingly contradictory possibilities along with various family historians online.
Edit: if anyone understands Y-DNA well enough, this
might clear things up somehow
Edit: added a generation I left out
submitted by cbjohnson73
to Genealogy [link] [comments]
2023.06.08 22:13 Tieden23 One block of E-Cores super hot
2023.06.08 21:40 Upwithstock What does CYDY look like after the clinical hold is lifted?
I just wanted to share my opinion about what I think is about to unfold. As we wait for the inevitable news to be announced that the "Clinical hold is lifted by the FDA", what happens next? One of the most important steps with any biotech that is trying to increase its value is receiving its first regulatory approval. Once a regulatory approval is achieved with a drug like Leronlimab, future approvals are less cumbersome. Future submissions are more streamlined because you have completed and submitted the foundational work that all future submissions are based on with LL. I have mentioned this before, Hospital formularies are easier to orchestrate once you have a drug on the formulary. You are basically just adding approved indications onto those formularies. Insurance reimbursements become slightly easier with each subsequent approval. But, before you get approval CYDY has to finish what it has started in the developmental phases. Cyrus has laid out a plan to all of us and that is represented in the 12-7-22 Investor presentation that can be seen in the 8K filed with the SEC on 12-7-22. In a nutshell, he prioritized NASH, Oncology and HIV/ NASH, but since that 12-7-22 date we have seen evidence of HIV expanded to HIV-Prep and HIV CURE (long acting LL). Even evidence that a 3rd party co-development partner has been established but not formally announce for HIV long acting. Could it be VIR?
CYDY has completed a phase 2 Nash study that was well received by the NASH community. The Oncology data has blown away Dr. Stefan Gluck a long time KOL in the Oncology space and of course CYDY has achieved positive clinical results and safety profile in a phase 3 HIV combo study that is stat significant. But once the clinical hold is lifted we need funding to move the development of LL forward and across the FDA finish-line. Where could that funding be coming from?
1) Private funding from the sale of warrants ? There does not appear to be enough shares left for a full scale funding effort to perform trials in any one indication let along multiple indications.
2) Issue a ton more shares that dilutes shareholders? We are currently trading at a manipulated .25-28 cents . Issuing more shares only lowers that to low double digits or maybe single digits depending on the amount of shares issued. And if this was truly the case, we investors would have seen some sort of effort to increase the stock price. Any effort! But, we have not seen that at all. IMO it is because Cyrus is extremely confident that he has secured funding commitments that are contingent on the Lifting of the clinical hold.
3) Buyout from a Big Pharma player. It is possible, there are signs pointing in that direction. If you look at this link about 12 signs my company is going be bought out, CYDY fits the criteria on a lot of those: https://www.griproom.com/fun/12-signs-a-company-is-being-bought-out
3a) But I don't believe we are getting bought out. Cyrus has done too much work in other areas to support a buyout thesis.
4) Amarex settlement: For me, this one is tough to assess. The only thing I am COMPLETELY CONFIDENT in is CYDY wins this settlement by a 100 miles. The question is how much? And when does CYDY receive the settlement? These factors are too out of CYDY's control. I don't know if Cyrus can bank on the amount and the when to say that he feels funding is secured. Maybe I am wrong and you can know the outcome of arbitration settlements before they are actually settled. I do know that; losing companies have filed bankruptcies in order to avoid the pay out or lessen the ruling or further delay the payment. IMO, one of the many strengths I see in Cyrus is he is a talented business guy and you don't count the uncountable. He needs something that is more concrete.
5) That concrete evidence for Cyrus is in Partnerships. Something he has worked with in his past. IMO Cyrus is setting CYDY up for long term success. He and Team CYDY are building the foundation to support that long term growth and he laid evidence of that out in the 12-7-22 plan. The partnership plan is going to be a sophisticated web of different types of partnerships that will bring in multiple partners with each one having a different twist to the partnership agreements. Scott Kelly said there are a 1000 ways to do partnerships. Whether you like Scott Kelly or not; there are a variety of ways to structure these things.
SO what will CYDY look like after the clinical hold is lifted? I think it starts with LIVIMMUNE and HIV. There is a model of this with GSK, Pfizer and Shionogi. They have a joint venture together to form ViiV. Viiv is a HIV company that is broken up between: 76.5% of the company is now owned by GlaxoSmithKline, 13.5% by Pfizer and 10% by Shionogi. More ViiV info: https://en.wikipedia.org/wiki/ViiV_Healthcare
What is interesting about ViiV is that ViiV Healthcare's products have a market share of approximately 19%
of the global HIV market, making it the second-largest healthcare company, after Gilead Sciences
, which is working on the treatment of HIV.
This brings me back to points I made at the beginning of this post. CYDY needs to cross the FDA finish-line and get approvals. THE QUICKEST WAY to do that is the resubmission of HIV MDR BLA. All of the required documents for the lifting of the clinical hold are also required for the BLA submission. CYDY has done the work already for the BLA re-submission by submitting many of those documents for the Lifting of the clinical hold. This to me is a perfect first step in a new Joint venture (with a twist) that LIVIMMUNE and VIR could create. With a future pipeline of long acting LL. This strategy is a great way to get the first approval and have a distribution partner in VIR put in place. Much better than the distribution agreement that NP created and ended up with Regnum. As some will recall Regnum has absolutely zero experience in the HIV space and zero sales force.
Let me comment on the Joint Venture with a twist with VIR. CYDY needs funding and generally speaking when you have a joint venture the different parties bring something to the party. CYDY has the asset (LL) and the completed phase 3 HIV MDR study. But no money for operations or future development. Since we have the asset and a completed HIV study ready for a BLA submission and eventual future PDUFA date. VIR can pay CYDY to be a part of that. VIR gets access to a HIV approval that would happen around 18 months: (6-9 months for an accepted BLA submission and 6-9 months for a PDUFA date.) IMO CYDY gets some funding from VIR to be a part of the HIV program at LIVIMMUNE.
Just a FYI on VIR, the last 10Q showed approximately $2.4 billion in cash and investments, and $1.5 Billion in revenue. Surely they can fork over $65 -$150 million for the rights to be involved with LIVIMMUNE?
What about Merck and Keytruda? All we know is that MD Anderson did a combo study in Oncology with LL/Keytruda. I believe we will know more about all of that after the lifting of the hold. Plus a possible partnership with Merck.
Lately, while we wait for the inevitable news of the lifting of the clinical hold, we get more information on CCR5's involvement in a particular disease state. Oncology was just going be MTNBC, and MGK pointed out from the September 2022 CC "17:50: So the near term financing requirements for the company will be focused on re-entering clinical trials for NASH as expeditiously as possible. Now while we do plan to continue development in oncology, our focus will be toward certain solid tumors to insure that we can collect sufficient data in enough patients within select indications, namely, colorectal cancer, breast cancer and potentially in non-small cell lung cancer with combination agents. We said colorectal cancer or CRC, we will be looking at the metastatic, microsatellite stable population
*. This represents about 85% of all the diagnosed cases of CRC. This particular segment of CRC hasn't seen any meaningful therapeutic advancement in nearly a decade. Yet, the Survival rates in that population have considerable room for improvement. In breast cancer, rather than focus on only the mTNBC population, which really only represents about 15% of the total growth cancer market and has seen increased competition advancements in check point inhibitors and antibody drug conjugates, we are going expand our focus into Hormone receptor positive HER2 negative population which stands for roughly about 70% of the total market. We believe that mCRC and mTNBC each represent large opportunity for leronlimab, and we believe that the mechanistic rationale for using the drug in those populations is quite strong for a CCR5 inhibitor. Let me be clear, that we intend to run these cancer studies over sufficient period of time to generate a robust and meaningful clinical data set that a potential partner would find compelling.*"
Multiple indications in Oncology and IMO means multiple potential partners in this space.
Once the Big Pharma players begin to really and I mean really understand the broad reach of LL and its effectiveness; They will want more of CYDY than ever before. They wont want to share indications and will have to step up in a BIG WAY to get their arms all the way around CYDY.
I have never been more confident than I am now about LL and the direction that we are headed. We are never going to be seeing this .26-.28 cents ever again.
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2023.06.08 20:39 facebookpromotion Solved: Instagram shopping account not approved
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Shop Can't be published
If your Instagram shopping account has not been approved, there are a few things you can check. First, ensure that your account meets Instagram's requirements for shopping accounts, such as having a business profile, being connected to a Facebook catalog, and being in compliance with Instagram's merchant agreement and commerce policies. Additionally, make sure that your account is in good standing, and that there are no issues such as a disabled account or a violation of community guidelines.
You can also try reaching out to Instagram's support team for further assistance. They may be able to provide more information on why your account was not approved, and what steps you can take to rectify the issue.
Your account has been rejected for a shop on Instagram
Your account has been rejected for a shop on Instagram
If your account has been rejected for a shop on Instagram, there may be a few reasons why this happened. Some possible reasons include:
- Your account does not meet Instagram's requirements for shopping accounts.
- Your account is not in good standing and may have been flagged for violating community guidelines or the merchant agreement.
- You may not have connected your account to a Facebook catalog.
- You may not have completed the necessary setup steps or provided all the required information for a shop account.
To resolve the issue, you can try reaching out to Instagram's support team for more information on why your account was rejected and what steps you can take to rectify the issue. Make sure to read the policies and guidelines again and check your account status. You can also try resolving any issues that may be causing the rejection.
Note that the process of getting your account approved for shopping feature on Instagram takes time, and it's good to read the policies and guidelines again before submitting your account for review.
Facebook shop and Instagram shop approved
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2023.06.08 20:23 fieffief Unable to populate map with markers using Google JS API
Hi, I've been delving the depths of StackOverflow, Reddit, and the documentation to get even one marker up on my map. I will need to make many more in the future. I am using Flask to send over some data to an html file, which is the accessed by an app.js. I am able to log that my API key and the locations JSON are accessible to the app.js file. I have used Postman to verify that I am getting a response that contains the latlng information via results.geometry.location. But even when I create the map and and make a simple marker with manually providing the latlng through "new google.maps.Marker(markerOptions);" and "marker.setMap(map);", nothing populates.
If I were to guess, it might be an issue with the google scripts in the html file being incorrect. I have added the Google JS script and more, and my app.js script is on the bottom in the order. home.html
[map url is passed through the home route (python): MAP_API_URL = ( "https://www.google.com/maps/embed/v1/view?key=" + API_KEY + "¢er=39.95233,-75.16379&zoom=14" )]